1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid sodium salt
sodium 1-hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylate
CAS: 51410-30-1
Molecular Formula: C16H7N2NaO5
1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid sodium salt - Names and Identifiers
| Name | sodium 1-hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylate |
| Synonyms | Catalin sodium pirenoxine sodium PIRENOXINE SODIUM Pirenoxine Sodium Salt sodium,1,5-dioxo-4H-pyrido[3,2-a]phenoxazine-3-carboxylate sodium 1-hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylate sodium 1,5-dioxo-1,5-dihydro-4H-pyrido[3,2-a]phenoxazine-3-carboxylate 1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid sodium salt 1-HYDROXY-5-OXO-5H-PYRIDO[3,2-A]PHENOXAZINE-3-CARBOXYLIC ACID MONOSODIUM SALT 1-Hydroxy-5-Oxo-5H-Pyrido[3,2-A]Phenoxazine-3-Carboxylic Acid Monosodium Salt |
| CAS | 51410-30-1 |
| EINECS | 257-181-6 |
| InChI | InChI=1/C16H8N2O5.Na/c19-9-5-8(16(21)22)18-14-10(20)6-12-15(13(9)14)17-7-3-1-2-4-11(7)23-12;/h1-6H,(H,18,19)(H,21,22);/q;+1/p-1 |
1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid sodium salt - Physico-chemical Properties
| Molecular Formula | C16H7N2NaO5 |
| Molar Mass | 330.23 |
| Boling Point | 515.8°C at 760 mmHg |
| Flash Point | 265.7°C |
| Vapor Presure | 1.83E-11mmHg at 25°C |
1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid sodium salt - Risk and Safety
| Toxicity | LD50 in mice (mg/kg): >10000 orally; >5000 s.c.; 2120-2250 i.p. LD50 in rats (mg/kg) i.p.: 2400 (males); 1460 (females) (Ikemoto) |
1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid sodium salt - Reference Information
| Function and use | The chemical structure of pirinoxine sodium is similar to the wormboxanthin compound. It is a pigment in the eyes of insects. It may have a competitive inhibitory effect on quinones. Basic and clinical extensive experiments have proved that it can prevent the development of cataract. This product is used to prevent the deterioration of cataracts caused by senile cataracts and diabetes. It is also used for traumatic and congenital cataracts and retinitis pigmentosa. |
| cataract drugs | one of the reasons for cataract formation is that soluble proteins in the lens are gradually turned into insoluble proteins under the action of quinones. Quinones are formed by the abnormal metabolism of tryptophan, an important functional amino acid in the body. The effect of this quinone substance on the soluble protein of the lens can be competitively inhibited by pirinoxine sodium, and it can also resist the cataract caused by free radical damage to the lens. Therefore, this product has a certain inhibitory effect on the development of cataracts. Studies have shown that pirinoxine sodium can reduce the incidence of capsular opacification after extracapsular cataract extraction. Uses: Mainly used for the treatment of early senile cataract, mild diabetic cataract or concurrent cataract. Adverse reactions: Allergies such as blepharitis and contact dermatitis may occur. Diffuse superficial keratitis, conjunctival congestion, irritation and itching were occasionally seen. If the above symptoms occur, the medication should be stopped. Very few patients have slight eye tingling. Note: For eye drops only. When dropping eyes, avoid contact between the mouth of the eye bottle and the eye to prevent contamination of eye drops. Fig. 1 shows pirinoxine sodium eye drops |
| adverse reactions | adverse reactions of pirinoxine sodium include: very few patients may have slight eye tingling. Occasionally diffuse superficial keratitis, blepharitis, conjunctival congestion, irritation, itching and other symptoms. |
| Drug interaction | The interaction between other drugs and pirinoxine sodium is not clear. Whether pirinoxine sodium can be used during pregnancy and lactation is not clear. How to use pirinoxine sodium drugs must be used rationally to avoid abuse. Prescription drugs should be prescribed by doctors, and over-the-counter drugs should be carefully read the drug instructions. Pirinoxine sodium is a prescription drug and must be prescribed by a doctor according to your condition. Self-medication may increase the risk of your irrational use of drugs: wasting drug resources, delaying the disease, causing drug resistance and serious adverse drug reactions. Pirinoxine sodium needs to be used in sufficient amounts and foot treatments as prescribed by the doctor. Your symptoms may be reduced before the condition is completely controlled, but don't reduce the dose or stop the drug easily. |
Last Update：2024-04-10 22:29:15
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